The Diverging Effects of Erythropoietin and U-74389gon ?-Glutamyl Transferase Levels

Aim: This study calculated the effects on gamma-glutamyltransferase (γgt) levels, after treatment with either of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.

Materials and methods: The 2 main experimental endpoints at which the serum γgtlevels (γgtl) were evaluated was the 60th reperfusion min (for the groups A, C and E) and the 120th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after the L administration.

Results: The first preliminary study of Epo presented a non significant hypο transfer asemic effect by 4.62%+12.56% (p-value=0.5534). The second preliminary study of U-74389G presented a non significant hyper transfer asemic effect by 1.24%+13.20% (p-value=0.8877). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that these 2 drugs have diverging metabolic effects on serum γgtl. (p-value=0.0000).

Conclusions: The anti-oxidant capacities of U-74389G ascribe anabolic effects rather than catabolic ones Epo ascribes to serum γgtl(p-value=0.0000).

Keywords: ischemia; erythropoietin; U-74389G; gamma-glutamyl transferase levels; reperfusion.